Drug resistance pattern of M. tuberculosis in category II treatment failure pulmonary tuberculosis patients

Ibrahim Medical College Journal Pub Date : 2014-01-20 DOI:10.3329/IMCJ.V7I1.17741

F. Rahman, S. Sharmin, M. Kamal, R. Miah

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Abstract

This study was designed to determine the extent of drug resistance of M . tuberculosis (MTB) isolated from category II treatment failure pulmonary tuberculosis (PTB) patients. A total of 100 Ziehl-Neelsen (Z-N) smear positive category II failure PTB patients were included in this study. Sputum culture was done in Lowenstein-Jensen (L-J) media. Conventional proportion method on Lowenstein-Jensen (L-J) media was used to determine the drug susceptibility of M. tuberculosis to isoniazid (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA). Out of 100 sputum samples, a total of 87 samples were positive by culture. Drug susceptibility test (DST) revealed that 82 (94.25%) isolates were resistant to one or more anti -TB drugs. Resistance to isoniazide (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA) was 94.25%, 82.75%, 29.90% and 3.45% respectively. Among these isolates, 79.31% and 3.45% isolates were multi-drug resistant (MDR) and extended drug resistant (XDR) M. tuberculosis respectively. High rate of anti-tubercular drug resistance was observed among the category II treatment failure TB patients. DOI: http://dx.doi.org/10.3329/imcj.v7i1.17741 Ibrahim Med. Coll. J. 2013; 7(1): 9-11

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ⅱ类治疗失败肺结核患者结核分枝杆菌的耐药模式

本研究旨在确定M。结核(MTB)从II类治疗失败的肺结核(PTB)患者中分离出来。本研究共纳入100例Ziehl-Neelsen (Z-N)涂片阳性II类失败PTB患者。痰液培养采用Lowenstein-Jensen (L-J)培养基。采用洛温斯坦-詹森(L-J)培养基常规比例法测定结核分枝杆菌对异烟肼(INH)、利福平(RMP)、氧氟沙星(OFX)和卡那霉素(KA)的药敏。100份痰液样本中，培养阳性87份。药敏试验显示，82株(94.25%)菌株对一种或多种抗结核药物耐药。对异烟肼(INH)、利福平(RMP)、氧氟沙星(OFX)和卡那霉素(KA)的耐药率分别为94.25%、82.75%、29.90%和3.45%。其中多重耐药(MDR)和扩展耐药(XDR)结核分枝杆菌分别占79.31%和3.45%。ⅱ类治疗失败的结核患者耐药率较高。DOI: http://dx.doi.org/10.3329/imcj.v7i1.17741 Ibrahim Med. col。j . 2013;7 (1): 9 - 11

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Ibrahim Medical College Journal

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