Therapy

Abstract

the Van Slyke method for determining the carbon dioxid capacity of the blood serum. It was found that three hourly doses of .1 cc. per kilogram of body weight of the typhoid-paratyphoid vaccine used in the former experiments produced a fever of three or more degrees in rabbits. Three such hourly doses of this vaccine were given to rabbits and hourly determinations of the carbon dioxid capacity of the blood plasma made. In the first experiment the temperature rose from 102.20 F. to 106.20 F. in the course of three hours, and returned to 1010 F. in the next four hours. The blood plasma binding power fell from 51.3 to 22.6 volumes per cent during the first four hours and rose to 35.4 volumes per cent at the close of the experiment.