The role of tranexamic acid in breast and body contouring surgery: a review of the literature

D. Wong, T. K. Lam
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引用次数: 1

Abstract

Background: Postoperative seroma and haematoma are two of the most common complications follow-ing large surface area surgeries. A review of the literature was performed to evaluate evidence for the use of tranexamic acid in reducing postoperative seroma and haematoma formation in breast surgery and body contouring surgery. Methods A literature search was performed using MEDLINE, the Cochrane Database of Systematic Review, the Cochrane Central Register of Controlled Trials (CENTRAL), the Database of Abstracts of Reviews of Ef-fect (DARE) and PubMed in English from 1 Jan 1990–30 Mar 2020. The search terms ‘TXA’, ‘breast reduction’, ‘mammaplasty’, ‘breast implants’, ‘breast implantation’, ‘breast reconstruction’, ‘mastectomy’, ‘tissue ex-pansion’, ‘body contouring’, ‘breast’ and ‘abdominoplasty’ were used alone and in combination. Results: A total of six articles were found including three randomised controlled trials, two cohort studies and one retrospective study. Two ongoing trials were found on The Cochrane Central Register of Con-trolled Trials (CENTRAL). No systematic reviews were found. Conclusion: Literature surrounding the use of TXA in breast and body contouring surgery is sparse com-pared to what is available in other surgical sub-specialties. The literature available shows promising results with the use of TXA in controlling haematoma, drain output and seroma formation in breast surgery and body contouring surgery with minimal morbidity in these patient groups.
氨甲环酸在乳房和身体整形手术中的作用:文献综述
背景:术后血清肿和血肿是大表面手术后最常见的两种并发症。对文献进行了回顾,以评估使用氨甲环酸减少乳房手术和身体轮廓手术中术后血肿和血肿形成的证据。方法检索1990年1月1日至2020年3月30日期间MEDLINE、Cochrane系统评价数据库、Cochrane中央对照试验注册库(Central)、ef - effect评价摘要数据库(DARE)和PubMed英文文献。搜索词“TXA”,“乳房缩小”,“乳房成形术”,“乳房植入”,“乳房植入”,“乳房重建”,“乳房切除术”,“组织扩张”,“身体轮廓”,“乳房”和“腹部成形术”被单独或组合使用。结果:共纳入6篇文献,包括3篇随机对照试验、2篇队列研究和1篇回顾性研究。在Cochrane中央对照试验登记册(Central)上发现了两项正在进行的试验。未发现系统评价。结论:与其他外科亚专科相比,关于在乳房和身体轮廓手术中使用TXA的文献很少。现有文献显示,在这些患者群体中,使用TXA在控制乳房手术和身体轮廓手术中的血肿、排液量和血肿形成方面有希望的结果,且发病率最低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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