The Effect of Pare (Momordica Charantia L.) Fruit Extract Fraction on Reducing Blood Sugar, Insulin Resistance and Phosphatidyl Inositol 3 Kinase (PI3K) Signalling in Male Rats (Rattus novergicus) Streptozotocin-induced Hyperglycemia

International Journal of Biomedical Herbal Medicine Pub Date : 2021-12-12 DOI:10.46880/ijbhm.v1i1.734

Gustiany Nadya Damanik, Hadyanto Lim

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Abstract

Background: Diabetes mellitus (DM) is a metabolic disease characterized by symptoms of hyperglycemia as a result of impaired insulin secretion. The main cause of type 2 diabetes mellitus is a metabolic disorder characterized by insulin receptor resistance, reduced ability of pancreatic -cells to secrete insulin, and abnormal insulin secretion from cells of the pancreatic islets of Langerhans. In insulin resistance, the signaling defect in Phosphatidylinositol 3-kinase (PI3K) causes impaired glucose regulation in the body. The purpose of this study was to determine the effect of bitter melon extract (Momordica charantia L.) on lowering blood sugar, insulin resistance, and phosphatidylinositol 3kinase (PI3K) signaling. Method: Literature review studies from related journals. Results: Based on research conducted, it is known that bitter melon extract has an effect on blood sugar, insulin resistance, and PI3K signaling. Conclusion: Bitter gourd extract has potential as an herbal antidiuretic drug.

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Pare (Momordica Charantia L.)的作用水果提取物对降低雄性大鼠(Rattus novergicus)链脲霉素诱导的高血糖、胰岛素抵抗和磷脂酰肌醇3激酶(PI3K)信号传导的作用

背景:糖尿病(DM)是一种以胰岛素分泌受损引起的高血糖为特征的代谢性疾病。2型糖尿病的主要病因是一种代谢紊乱，其特征是胰岛素受体抵抗，胰腺细胞分泌胰岛素的能力下降，朗格汉斯胰岛细胞分泌胰岛素异常。在胰岛素抵抗中，磷脂酰肌醇3-激酶(PI3K)的信号缺陷导致体内葡萄糖调节受损。本研究的目的是确定苦瓜提取物(Momordica charantia L.)对降低血糖、胰岛素抵抗和磷脂酰肌醇3激酶(PI3K)信号传导的影响。方法:查阅相关文献。结果:根据研究，苦瓜提取物对血糖、胰岛素抵抗和PI3K信号传导有影响。结论:苦瓜提取物具有作为抗利尿药物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Biomedical Herbal Medicine

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