Clinical-morphological and immunohistochemical characteristics of adenomas of the anterior pituitary lobe

S. V. Petrov, Ya.S. Abuzova, N. Gizatullina, E. O. Sokolova
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Abstract

Introduction Clinical and morphological characterization of pituitary adenomas remains a topical problem of great importance in view of lesions in persons of working age.Purpose of work was to identify clinically relevant morphological and immunohistochemical features of pituitary adenomas.Material and Methods Sixty-two adenomas were studied: 25 in men and 37 in women. Pituitary adenoma was most frequently diagnosed between 51 and 70 years of age. Adenomas were mostly of small and medium size with predominance of supra- and laterosellar location. There were 41 hormone-positive adenomas and 21 “dumb” neoplasms without signs of trophic hormone synthesis. Gonadotropinomas and corticotropinomas prevailed among hormone-positive adenomas. Ki67 index in our material did not exceed 1−2%, which is a favorable prognostic factor for low recurrence of adenomas.Results 62 adenomas were studied, 25 in men and 37 in women. Vast majority of adenomas were diagnosed at the age of 51 to 70 years. Adenomas mainly had small and medium size, with a predominance of supra- and laterosellar localization. Out of 62 adenomas 41 were hormone-positive, and 21 were “silent” neoplasms without signs of synthesis of trophic hormones. Among hormone-positive adenomas, most were gonadotropinomas and corticotropinomas. The Ki67 index in our material did not exceed 1-2%, which is a favorable prognostic factor for low recurrence of adenomas.Discussion In contrast to previously published works, gonadotropinomas and corticotropinomas prevailed in our material. The most diagnostically important markers were identified and applied for routine morphological verification of pituitary adenomas.Conclusion The predominance of hormone-positive adenomas of small size was a peculiarity of the work. At the same time, hormone-positive tumors had no clinical manifestations for quite a long time and were latent. Low proliferativity of the studied adenomas was a favorable prognostic sign.
垂体前叶腺瘤的临床形态学和免疫组织化学特征
垂体腺瘤的临床和形态学特征仍然是一个非常重要的局部问题,鉴于病变的工作年龄的人。工作的目的是确定临床相关的垂体腺瘤的形态学和免疫组织化学特征。材料与方法对62例腺瘤进行了研究,其中男性25例,女性37例。垂体腺瘤最常见于51岁至70岁之间。腺瘤多为中小型,以鞍上及鞍侧为主。41例激素阳性腺瘤和21例无营养激素合成征象的“哑”瘤。促性腺瘤和促皮质腺瘤在激素阳性腺瘤中居多。在我们的研究中,Ki67指数不超过1 - 2%,这是腺瘤低复发率的有利预后因素。结果共62例腺瘤,其中男性25例,女性37例。绝大多数腺瘤在51至70岁时被诊断出来。腺瘤以中小型为主,以鞍上和鞍侧为主。62例腺瘤中41例激素阳性,21例为无营养激素合成征象的“沉默”肿瘤。在激素阳性的腺瘤中,大多数是促性腺瘤和促皮质腺瘤。在我们的材料中,Ki67指数不超过1-2%,这是腺瘤低复发率的有利预后因素。与以前发表的作品相反,我们的材料中主要是促性腺激素瘤和促皮质腺瘤。确定了最重要的诊断标记,并应用于垂体腺瘤的常规形态学验证。结论小尺寸激素阳性腺瘤的优势是该工作的特点。同时,激素阳性肿瘤在相当长时间内无临床表现,具有潜伏性。所研究的腺瘤的低增殖是一个良好的预后迹象。
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