Personalized Nutrition Service for Anti-fatigue Based on Genomics

Abstract

The fatigue symptoms such as persistent sense of tiredness, low mood, difficult to concentrate, headache, and sleep disorder affects people’s normal working state, learning situation, and sports ability. Therefore, it’s very helpful to find anti-fatigue solutions to keep people in a healthy and vigorous status so that to work, study, and do exercise efficiently. Both genetic and lifestyle factors are related to fatigue. Many genes such as MTR, SHMT1, CAT, NQO1, COMT, ACTN3, Clock, HFE, MTHFR have been identified as being associated with the methylation function, muscle performance, mitochondrial function, erythrocyte characteristics, endocrine hormone, sleep quality, and nutritional requirement, which further affect fatigue. For instance, the lack of sleep can lead to mental fatigue, impaired decision-making and learning ability, the Clock gene is linked with sleep disorders and biological rhythms. Lifestyles such as diet, sport, smoking, history of diseases are also related to fatigue, for instance, vitamin B2 deficiency will affect the tricarboxylic acid cycle and cell respiratory chain, affect the production of energy and the delivery of blood oxygen, stimulate iron deficiency anemia, and lead to systemic fatigue and muscle weakness. In this paper, analyzing the genetic and lifestyle data together, we give a personalized nutrition service for each customer and produce a corresponding personalized product for the customer.