Differentiation of spontaneous locomotor activity affects the spatial reference memory level in Water Morris test in rats

Abstract

Novelty test, used as a model of stress reactivity (sensitivity/resistance to stress), allows to divide animals according to their level of locomotor response to novelty into high (HRs-) and low (LRs-) responders. These behavioral differences reflect a number of differences, including the level of anxiety, which could affect memory processes and learning. The presented study aimed to determine the effect of differences in spontaneous locomotor activity on the level of spatial reference memory in basal conditions in rats which will be exposed to a sporadic form of Alzheimer's disease (sAD)-induced cognitive impairment in the next stage of the experiment.