THE EFFECT OF ENTEROSORPTION AND INTRATISSUE ELECTROPHORESIS OF ANTIBIOTICS ON THE COURSE OF THE WOUND PROCESS IS IN CASE OF THERMAL BURNS

Abstract

Summary. Aim. Investigation of the enterosorption impact of the Enterosgel and intratissue electrophoresis (ITE) of antibiotics on the course of the wound process in case of widespread dermal thermal burns. Materials and methods. The clinical efficacy of this combination was studied in 22 patients with superficial and deep dermal burns (Vishnevsky grade IIIA-B) with an area of 25 % to 62 % of the total body. Enterosgel in the form of a suspension with water was administered from the 3rd day after the injury, 15–20 g 3–4 times a day for 7–12 days. ITE of Antibiotics were performed from day 2–3 using the “Potok-1” apparatus with a constant current density of 0.03–0.05 mA/cm2 for 45–60 minutes. Visual assessment of the dynamics of the wound process, planimetric and cytological examination of burn wounds exudate in the dynamics on days 1–3, 6–7, 13–14 and 19–21 from the moment of injury were performed. Results and discussion. The proposed combination of these agents in the complex treatment of victims with widespread dermal thermal burns helps to optimize the course of the wound process in the area of thermal injury. At the same time, both demarcation and cleansing processes as well as reparative regeneration are activated, which increases the clinical effectiveness of the prescribed treatment. Conclusions. As a result of the clinical study, it was found that the use of intravenous antibiotics in combination with oral administration of enterosgel in the complex treatment of victims with widespread burns is reasonable and appropriate.