The effect of changes in blood volume on low frequency blood pressure fluctuations in spontaneously hypertensive rats

[1989] Proceedings. Computers in Cardiology Pub Date : 1989-09-19 DOI:10.1109/CIC.1989.130481

O. Oz, S. Eliash, S. Cohen, S. Akselrod

{"title":"The effect of changes in blood volume on low frequency blood pressure fluctuations in spontaneously hypertensive rats","authors":"O. Oz, S. Eliash, S. Cohen, S. Akselrod","doi":"10.1109/CIC.1989.130481","DOIUrl":null,"url":null,"abstract":"This study is based on the hypothesis that the development of essential hypertension is due to a defect in cardiovascular control. Young, prehypertensive, spontaneously hypertensive (SHR) rats were compared with normotensive Wistar Kyoto (WKY) rats. Spectral analysis of blood pressure (ABP) fluctuations previously demonstrated that baseline low-frequency fluctuations (0.04-0.1 Hz) are reduced in the SHR rats even before they develop hypertension. In the present study, 20-min-long ABP traces were sampled with the focus on frequencies as low as 0.004 Hz. The effect caused by a perturbation in blood pressure was investigated in young SHR versus WKY rats. A sudden drop in blood volume (2-ml bleeding) caused a clear increase in low-frequency ABP fluctuations, more pronounced in SHR than in WKY rats. The decrease in mean ABP was larger in SHR (-42%) than in WKY rats (-21%). Alpha/sub 1/-blockade (prazosin) affected the reaction of both species to bleeding differently. The results indicate that the SHR rats exhibit an abnormal nervous response ( alpha -sympathetic) to a drop in blood pressure, which might be at the basis of the development of hypertension.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"[1989] Proceedings. Computers in Cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/CIC.1989.130481","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

Abstract

This study is based on the hypothesis that the development of essential hypertension is due to a defect in cardiovascular control. Young, prehypertensive, spontaneously hypertensive (SHR) rats were compared with normotensive Wistar Kyoto (WKY) rats. Spectral analysis of blood pressure (ABP) fluctuations previously demonstrated that baseline low-frequency fluctuations (0.04-0.1 Hz) are reduced in the SHR rats even before they develop hypertension. In the present study, 20-min-long ABP traces were sampled with the focus on frequencies as low as 0.004 Hz. The effect caused by a perturbation in blood pressure was investigated in young SHR versus WKY rats. A sudden drop in blood volume (2-ml bleeding) caused a clear increase in low-frequency ABP fluctuations, more pronounced in SHR than in WKY rats. The decrease in mean ABP was larger in SHR (-42%) than in WKY rats (-21%). Alpha/sub 1/-blockade (prazosin) affected the reaction of both species to bleeding differently. The results indicate that the SHR rats exhibit an abnormal nervous response ( alpha -sympathetic) to a drop in blood pressure, which might be at the basis of the development of hypertension.<>

查看原文本刊更多论文

血容量变化对自发性高血压大鼠低频血压波动的影响

本研究的假设基础是原发性高血压的发生是由于心血管控制的缺陷。将年轻、高血压前期、自发性高血压大鼠(SHR)与正常血压的Wistar Kyoto大鼠(WKY)进行比较。先前对血压(ABP)波动的频谱分析表明，SHR大鼠的基线低频波动(0.04-0.1 Hz)甚至在发生高血压之前就减少了。在本研究中，对20分钟长的ABP迹线进行采样，重点频率低至0.004 Hz。在年轻的SHR和WKY大鼠中研究了血压扰动引起的影响。血容量突然下降(2毫升出血)导致低频ABP波动明显增加，在SHR大鼠中比在WKY大鼠中更为明显。SHR组平均ABP下降幅度(-42%)大于WKY组(-21%)。α /亚1/-阻断剂(prazosin)对两种动物出血反应的影响不同。结果表明，SHR大鼠对血压下降表现出异常的神经反应(α -交感神经)，这可能是高血压发展的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

[1989] Proceedings. Computers in Cardiology

自引率

0.00%

发文量