Capability of Bacterial Cellulose Membrane in Release of Doxycycline

Abstract

Bacterial cellulose produced by Gluconacetobacter xylinus is an advantage bacterial product cause of its unique properties, could be used as an ideal dress. The aim of this study was to consider the capability of this biomaterial in release of doxycycline. Proving of this capability provided the outline for production of a dressing containing antibiotic. In this study, bacterial cellulose was synthesized by G.xylinus and loaded from doxycycline then release process was considered in dilute water and buffer phosphate saline. UV-visible spectrophotometry method was applied to measuring the concentration of released drug. Bacterial cellulose structure of chemical was confirmed by Fourier Transform Infrared spectroscopy. Release of doxycycline in dilute water and phosphate saline buffer reach to 73.25% and 94.9%, respectively. Because of more released in buffer solution, peer that process of releasing exhibit exactly results. Results of this study provided the ground for future research on supplying an ideal dressing from this microbial product.