LAP (produto da acumulação lipídica) e síndrome metabólica em pacientes com síndrome dos ovários policísticos

Abstract

Introduction

Polycystic Ovary Syndrome (SOP) is a common endocrine disorder that affects 5‐10% of women of reproductive age. The association between metabolic syndrome and changes related to glucose and insulin is frequent in patients with SOP, increasing the cardiovascular risk of these patients. The LAP is an emerging cardiovascular risk based on the combination of waist circumference (WC) and triglycerides (TGL) and fasting simply reflects the lipid accumulation in adults.

Objectives

This study examined the possible correlation between metabolic syndrome or LAP and reproductive and metabolic parameters in patients with SOP.

Materials and Methods

The study included two hundred ninety‐nine patients with SOP, defined by the Rotterdam criteria followed at HC‐UFMG who had assessed their levels of triglycerides, total testosterone, fastingand two hours after 75 grams of overload dextrosol (GPD), TSH, LAP, Ferriman index, ovarian volume and abdominal circumference, and the presence or absence of metabolic syndrome.

Results

The mean LAP was 60.9 and the median 51.3. Patients with and without metabolic syndrome when compared to each others howed no differences in ovarian volume, total testosterone, Ferriman, fastingand post‐dextrosol. Women with metabolic syndrome had higher TSH levels than women without metabolic syndrome. The women in the top quartile of the LAP had TSH, Ferriman and GPD higher than women in the lower quartiles of LAP.

Conclusions

The higher values of LAP suggested good correlation of this index with insulin resistance. TSH levels were higher in patients with metabolic syndrome and LAP in the top quartile in SOP patients represent a new element in the literature and needs to be better studied.