MicroRNAs as Regulatory Elements of Mammalian Spermatogenesis

F. Malekvandfard, L. Zare, S. M. Farsani, M. Motavaf
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Abstract

: In recent decades, infertility is becoming a public health issue. Male spermatogenesis failure has been considered a major contributory factor to infertility. Mammalian spermatogenesis is a well-defined process, requiring highly regulation processes in both transcriptional and the posttranscriptional levels. Discovery of microRNAs (miRNAs or miR) as essential class of gene expression regulators has provided new insights into a multitude of biological processes including spermatogenesis. In current review study, we first provide a short overview of spermatogenesis process, and then focus on recent studies that have elucidated the essential role of miRNAs in different steps of sperm production.
哺乳动物精子发生的microrna调控元件
近几十年来,不孕症正在成为一个公共卫生问题。男性精子发生失败被认为是导致不育的主要因素。哺乳动物精子发生是一个定义明确的过程,需要在转录和转录后水平高度调控的过程。microRNAs (miRNAs或miR)作为一类重要的基因表达调控因子的发现,为包括精子发生在内的众多生物过程提供了新的见解。在目前的综述研究中,我们首先简要概述了精子发生的过程,然后重点介绍了最近的研究已经阐明了mirna在精子产生的不同步骤中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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