Response of serum zinc and copper to inflammatory stimulation in the rat with chronic liver damage.

Archivos de investigacion medica Pub Date : 1991-07-01

J Garduño Espinosa, R Paniagua Sierra, S Díaz Bensussen, A Lifshitz

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Abstract

Objective of the study: To measure the seric levels of zinc and copper in healthy and in hepatic damaged rats when an inflammatory stimulus is applied.

Research design: 2 x 2 factorial design.

Subjects: Fisher *44 strain rats, healthy and with chronic hepatic damage.

Measurements: Serum levels of Zn and Cu were determined in the different experimental conditions.

Results: Basal Zn levels were found diminished in rats with hepatic damage as compared with healthy ones (p < 0.05), whereas Cu levels were found increased in hepatic damaged rats as compared with healthy ones (p < 0.05). Application of an inflammatory stimulus decreased Zn and increased Cu levels in healthy rats as compared to their basal conditions (p < 0.05), whereas no statistically significant variations were found in the group of rats with hepatic damage when comparing their serum levels before and after inflammatory stimulation.

Conclusions: Rats with liver damage present alterations in their Zn and Cu levels under basal conditions. Rats with liver damage, submitted to an inflammatory stimulus, do not modify their serum Zn and Cu levels.

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慢性肝损伤大鼠血清锌、铜对炎症刺激的反应。

目的:研究炎症刺激对健康大鼠和肝损伤大鼠血清锌、铜水平的影响。研究设计:2 × 2因子设计。实验对象:Fisher *44株大鼠，健康，慢性肝损伤。测定方法:测定不同实验条件下血清锌、铜水平。结果:肝损伤大鼠的基础锌水平较健康大鼠降低(p < 0.05)，而肝损伤大鼠的基础铜水平较健康大鼠升高(p < 0.05)。在健康大鼠中，与基础条件相比，炎症刺激降低了锌水平，增加了铜水平(p < 0.05)，而在肝损伤大鼠组中，炎症刺激前后的血清水平比较，没有发现统计学上的显著变化。结论:肝损伤大鼠在基础条件下存在锌、铜水平的改变。肝损伤的大鼠，在炎症刺激下，不改变其血清锌和铜水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Archivos de investigacion medica

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