The Effects of Glutamine in the Treatment of Irritable Bowel Syndrome

Abstract

This systematic review study aimed to analyze the effects of glutamine on irritable bowel syndrome, demonstrating the adequate dose of glutamine for the treatment of IBS and identifying which clinical symptoms are improved with glutamine supplementation that include a relationship with the restoration of the intestinal wall, increase of immune cells, among other effects. Forth research, a systematic literature review of articles published between 2011 and 2021 was carried out. The research demonstrated that glutamine supplementation helps to protect the intestinal mucosa, increasing the capacity of immune cells, decreasing the translocation of bacteria and toxins after intestinal injury, preventing infections and inflammation, improving the symptoms of individuals with IBS. It is concluded that glutamine supplementation enhances the synthesis of this amino acid, which is extremely important in situations of metabolic stress and to exercise activities related to intestinal villi, consequently improving nutrient absorption.