A Meta-Analysis on the Relationship Between Derivatization and Cytotoxicity of Chalcone Compound

Abstract

Cancer is a worldwide leading cause of death. The development of an effective anti-cancer drug is with pressing need. Chalcone and its derivatives have been considered as general anti-cancer compounds. Because of its easy synthesis and good biological activity, Chalcones has attracted extensive attention. However, the potency of Chalcones to various cancer types and the ideal modification site on Chalcones has not been well documented. Herein, we systematically retrieved multiple pieces of literature from the Web-Of-Science search engine and examined chalcone derivatization literature from 2017 to 2022. Through meta-analysis, we found significant heterogeny between the cytotoxicity effects of chalcone compounds between normal cells and cancer cells (P <0.05). Chalcone derivatives indicate different potency to glioma (mean 0.46 μM), skin cancer (mean 6.63 μM), colon cancer (mean 7.87 μM), colorectal cancer (mean 8.12 μM), and brain cancer (mean 9.53 μM). Moreover, the modification site also statistically correlates to the potency of Chalcone derivatives. Among fluorine, bromine, chloride modifications, ortho chlorine substitution shows the optimal potency as indicated by the minimum overall mean IC50 values.