Responses of neutrophils and lymphocytes in the cold stress: effects of nonsteroid anti-inflammatory drugs.

T Garbuliński, B Obmińska-Domoradzka, M Switała, J Debowy
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Abstract

The cold stress induced in rabbits by lowering their body temperature by 3 degrees C resulted in neutrophilia and a decrease in number of phagocytes and phagocytized bacteria. The stress did not affect the number of lymphocytes and the ability of forming E rosettes by T lymphocytes, but depressed the formation of EAC rosettes by B lymphocytes. This inhibition of neutrophil activity was antagonized completely by acetylsalicylic acid, and substantially by mefenamic acid and indomethacin administered, in doses inhibiting pyrogen-induced fever, either 2.5 h before or 1.5 h after the hypothermia. The drugs did not antagonize the depression of the ability of formation of EAC rosettes.

中性粒细胞和淋巴细胞在冷应激中的反应:非甾体抗炎药的作用。
家兔体温降低3℃引起的冷应激导致嗜中性粒细胞增多,吞噬细胞和被吞噬细菌数量减少。应激不影响T淋巴细胞形成E型莲座的能力,但抑制了B淋巴细胞形成EAC型莲座的能力。这种对中性粒细胞活性的抑制作用被乙酰水杨酸完全拮抗,并被甲氧胺酸和吲哚美辛充分拮抗,在低温治疗前2.5 h或后1.5 h,以抑制热原诱导的发热的剂量施用。这些药物对EAC花环形成能力的抑制没有拮抗作用。
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