[The characteristics of the initial link in the intestinal lesion by opportunistic Proteus mirabilis bacteria].

Abstract

Interaction of Proteus mirabilis with the intestine epithelium in white mongrel mice has been studied by means of bacteriological, toxicological and electron microscopic methods. Introduction of the agar culture of bacteria to the intestine lumen has permitted finding its general toxic action on enterocytes and other cell elements of epithelium which was accompanied by a potentiation of the striated margin membrane degradation but caused no destruction of cells. A damaging factor of protei was connected with the thermostable large-molecular fraction of cultural fluid of bacteria and its action was traced at the first hours of the bacterial contact with the mucous surface of thin intestine. Preliminary weakening of protective barriers of the intestine mucosa permitted protei to penetrate deep into the tissue through the intercellular slots. Colonization of the intestine lumen wall zone by the proteus is a necessary condition of the above-mentioned changes.