Nickel chloride: potential accumulation from the airway. Toxicokinetics in rats.

E B Novelli, N L Rodrigues
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Abstract

The rate removal of nickel from the airway was measured in vivo. Removal in vivo was studied by intratracheal injection of nickel chloride solutions. Regardless of time after injection, the lungs and heart retained the greatest concentration of nickel and 40 days after 1.68 mumol administration they were the organs where nickel was still significantly measurable. The slow removal of nickel may indicate the presence of high affinity binding sites in the lung. Nickel can interact with others metals, such as copper and zinc, so that nickel exposure may have public health implications.

氯化镍:可能从气道积聚。大鼠的毒性动力学。
在体内测量了镍从气道中去除的速率。通过气管内注射氯化镍溶液,研究其在体内的去除效果。无论注射后多长时间,肺和心脏的镍浓度都最高,注射1.68 mumol后40天,肺和心脏仍是镍含量显著的器官。镍的缓慢去除可能表明在肺中存在高亲和力结合位点。镍可以与铜和锌等其他金属相互作用,因此接触镍可能对公众健康产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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