Mechanical properties and immunogenicity of vascular xenografts.

Y Murayama, S Sato, T Oka
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引用次数: 3

Abstract

Polyepoxy compounds (PC) have been introduced as new cross-linking agents to overcome some of the disadvantages of glutaraldehyde (GA). In this study, we investigated the relationship of the reaction time to the immunogenicity and mechanical properties of canine and bovine common carotid arteries cross-linked with one of PC, namely, glycerol polyglycidyl ether (GPE). To evaluate mechanical properties, we made use of the finite deformation theory. Arteries cross-linked with GPE for 48 hours proved to be about 3 times as flexible as those cross-linked with GA for 48 hours. In the immunogenicity experiments, GPE was observed to reduce the immunogenicity of the arteries according to the reaction time, and the arteries, which were cross-linked with GPE for 48 hours, showed little immunogenicity. It was concluded that GPE is a more suitable cross-linking agent than GA, and its optimum reaction time seems to be 48 hours.

异种血管移植物的力学特性和免疫原性。
聚环氧化合物(PC)是一种新型交联剂,克服了戊二醛(GA)的一些缺点。在这项研究中,我们研究了反应时间与交联的一种PC,即甘油聚缩水甘油酯醚(GPE)的犬和牛颈总动脉的免疫原性和力学性能的关系。为了评价其力学性能,我们采用了有限变形理论。经证实,与GPE交联48小时的动脉柔韧性是与GA交联48小时动脉柔韧性的3倍左右。在免疫原性实验中,根据反应时间观察到GPE降低了动脉的免疫原性,与GPE交联48小时的动脉免疫原性不明显。结果表明,GPE是比GA更合适的交联剂,其最佳反应时间为48 h。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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