Change in the acid protease activity in plasma of patients with disseminated intravascular coagulation.

S Uetsuji, M Yamamura, T Tanaka, M Yamamoto
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引用次数: 1

Abstract

Lysosomal protease was determined in the serum of patients with disseminated intravascular coagulation (DIC) to clarify whether the platelet count is an appropriate diagnostic index which allows the early initiation of treatment. The platelet count and the serum level of cathepsin D, a lysosomal protease, were determined in 60 patients diagnosed to have DIC. The cathepsin D activity could not be detected in the sera of healthy individuals with a platelet count of 100,000 or above, but was detectable in the serum of DIC patients with a platelet count of 100,000, and this activity increased as the platelet count decreased to 70,000 and 50,000, and was about 5 times higher at a platelet count of 30,000 than at 70,000. In DIC patients, the decrease in the platelet count was correlated with the increase in the serum lysosomal protease activity. The appearance of cathepsin D activity in the serum of DIC patients is considered to reflect the release of lysosomal enzyme activities from damaged organs, and the treatment for DIC must be initiated before the platelet count decrease below 100,000, and cathepsin D activity then appears in the serum. At a platelet count of 30,000 or less, DIC becomes established, and no therapeutic effects can be expected because of the associated multiple organ failure.

弥散性血管内凝血患者血浆酸性蛋白酶活性的变化。
通过对弥散性血管内凝血(DIC)患者血清溶酶体蛋白酶的测定,阐明血小板计数是否为早期治疗的合适诊断指标。对60例诊断为DIC的患者进行血小板计数和血清组织蛋白酶D(溶酶体蛋白酶)水平测定。组织蛋白酶D活性在血小板计数10万及以上的健康人血清中无法检测到,但在血小板计数10万的DIC患者血清中可检测到,血小板计数下降到7万和5万时,组织蛋白酶D活性增加,血小板计数为3万时比7万时高约5倍。DIC患者血小板计数下降与血清溶酶体蛋白酶活性升高相关。DIC患者血清中组织蛋白酶D活性的出现被认为反映了受损器官溶酶体酶活性的释放,DIC的治疗必须在血小板计数降至100,000以下之前开始,然后在血清中出现组织蛋白酶D活性。当血小板计数为30000或更少时,DIC成为确定的,并且由于相关的多器官衰竭而无法预期治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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