Animal models of T-cell acute lymphoblastic leukemia: mimicking the human disease

Q. You, H. Su, Jingchao Wang, Jue Jiang, Guoliang Qing, Hudan Liu
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引用次数: 3

Abstract

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic abnormalities. In the past decade, large-scale genomic analysis has shed new light on providing potentially important oncogenic or tumor suppressive candidates involved in the disease progression. Following in silico analysis, functional studies are usually performed to vigorously investigate the biological roles of candidate genes. For this purpose, animal models faithfully recapitulating the human disease are widely applied to decipher the mechanism underlying T-cell transformation. Conversely, an increased understanding of T-ALL biology, including identification of oncogene NOTCH1, TAL1 and MYC as well as tumor suppressor phosphatase and tensin homolog (PTEN), has significantly improved the development of T-ALL animal models. These progresses have opened opportunities for development of new therapeutic strategy to benefit T-ALL patients. In this review, we particularly summarize the mouse and zebrafish models used in T-ALL research and also the most recent advances from these in vivo studies.
t细胞急性淋巴细胞白血病动物模型:模拟人类疾病
摘要:t细胞急性淋巴细胞白血病(T-ALL)是一种异质性的血液学肿瘤,由不同的亚型组成,其遗传异常各不相同。在过去的十年中,大规模的基因组分析揭示了新的线索,提供潜在重要的致癌或肿瘤抑制候选物参与疾病进展。在计算机分析之后,通常进行功能研究,以大力研究候选基因的生物学作用。为此,忠实地再现人类疾病的动物模型被广泛应用于破译t细胞转化的机制。相反,对T-ALL生物学的进一步了解,包括癌基因NOTCH1、TAL1和MYC以及肿瘤抑制磷酸酶和紧张素同源物(PTEN)的鉴定,显著改善了T-ALL动物模型的开发。这些进展为开发新的治疗策略提供了机会,使T-ALL患者受益。在这篇综述中,我们特别总结了用于T-ALL研究的小鼠和斑马鱼模型以及这些体内研究的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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