A REVIEW ON FLOATING DRUG DELIVERY SYSTEM

Abstract

The purpose of this review on floating drug delivery systems (FDDS) is to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profiles in the gastro intestinal tract is to control the gastric residence time, using gastroretentive dosage forms that will provide us with new and important therapeutic options. From the formulation technological point of view, the floating drug delivery system is considerably easy and better approach. The development of FDDS are including physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems, advantages, formulation variables and their classifications are covered in detail. This review also summarizes the in vitro techniques, the in vivo studies to evaluate the performance and application of floating systems. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. An attempt has been made in this review article to introduce the readers to the current technological developments in floating drug delivery.