Molecular optical probes for imaging tumors

Abstract

Biomedical optical methods provide distinctly new diagnostic capabilities while complementing conventional imaging modalities. To be effective, the molecular probes should produce detectable, quantifiable and discernable signals in response to light absorption or biological activation. Presently, fluorescein, indocyanine green (ICG) and fluorescent photosensitizers are widely used as optical molecular probes for in vivo imaging of tumors, possibly due to their established photophysical properties and safety profile in humans.