Mass Surgical Treatment of Obesity and Type-2 Diabetes: Now is the Right Time

M. Gagner
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引用次数: 0

Abstract

Copyright © 2015, Minimally Invasive Surgery Research Center and Mediterranean & Middle Eastern Endoscopic Surgery Association. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. I recently wrote a provocative commentary (1) following the article written by Anita Courcoulas on in JAMA surgery (2). After the Second World War, with the raise of tobacco usage, high alcohol concentrations intake, urban pollution, high fat diets and sedentary lifestyle, coronary atherosclerotic disease became one of the most important public enemy. The response came in 1950, at McGill University in Montreal, where Vineberg and Buller were the first to implant an internal mammary artery into the myocardium to treat cardiac ischemia and angina (3). Indeed, coronary disease peaked in the sixties and seventies, and saphenous vein graft coronary bypasses popularized by the Argentinian Rene Favaloro, while he worked at the Cleveland Clinic, increased exponentially (4). Mass surgical treatment took its course, with cardiac surgical institutes growing like mushrooms everywhere in the world. Hospitals were built solely on this pathology, with cardiologists, coronarographers, perfusionnists and dedicated cardiac surgeons doing more than half a million procedures a year in USA, and an estimated > 1 million per year worldwide (4). That volume has recently gone down by almost half these numbers, from interventional cardiology, but mostly from a decrease in tobacco and alcohol usage, a better lesser fat diet, statins and increased regular exercises (in lesser local atmospheric pollution). Is it possible that in order to target obesity and type2 diabetes, we have to go the same path? That is, mass surgical treatment, is again ahead of lifestyle changes and medical treatment. We should be building obesity/ diabetes institutes, entire hospitals with multidisciplinary teams, complete with internists, endocrinologists, bariatric and metabolic surgeons, psychologists and nutritionists, as well as public health stakeholders. We could operate millions of affected patients in the World and really have an impact on those 2 chronic diseases, as there is an estimate of 350 million affected (5). We should be operating fast enough, so that the new pool of patients would not overlap on the ones we are treating annually. Already, with the rapid rise of sleeve gastrectomy, the number one choice in USA, 200,000 patients are operated annually, and perhaps a projected < 500000 operations per year in the globe for 2015. That is not enough; we should be doing 10 times these numbers, at the very least. Even at 5 million patients per year, it would take us 70 years to operate everybody. But that is a reasonable goal in the short-term. It would take a procedure that is relatively brief, with few complications, a very low mortality rate, reproducible and has acceptable long-term results. At this time, laparoscopic sleeve gastrectomy would fit this profile (GERD can be treated medically), better that Roux-en-Y gastric bypass, as it may have longterm bowel obstruction risks, ulcer risks, micronutrients severe deficiency, bone disease, and 10% hypoglycemia/ dumping syndromes (6, 7). Sleeves gastrectomies can be revised more easily with numerous options. Also, I can do 3 sleeves while one gastric bypass is being done in the same time interval, as we have a surgical manpower problems, the former is preferable. Is it time for mass surgical treatment of obesity and type-2 diabetes? Yes, now is the right time.
肥胖和2型糖尿病的大规模手术治疗:现在是正确的时机
版权所有©2015,微创外科研究中心,地中海和中东内镜手术协会。这是一篇在知识共享署名-非商业4.0国际许可(http://creativecommons.org/licenses/by-nc/4.0/)条款下发布的开放获取文章,该许可允许在原始作品适当引用的情况下,仅以非商业用途复制和再分发材料。我最近在《美国医学会杂志》上发表了Anita Courcoulas的一篇文章(2),随后我写了一篇挑衅性的评论(1)。第二次世界大战后,随着烟草使用量的增加、高浓度酒精的摄入、城市污染、高脂肪饮食和久坐不动的生活方式,冠状动脉粥样硬化疾病成为最重要的公敌之一。1950年,蒙特利尔的麦吉尔大学做出了回应,vinberg和Buller是第一个将乳房内动脉植入心肌以治疗心脏缺血和心绞痛的人(3)。确实,冠状动脉疾病在六七十年代达到顶峰,而由阿根廷人Rene Favaloro推广的隐静脉冠状动脉旁路搭桥术在克利夫兰诊所工作时呈指数增长(4)。心脏外科研究所如雨后春笋般在世界各地发展。医院完全建立在这种病理基础上,心脏病专家、冠状动脉医师、灌注师和专门的心脏外科医生在美国每年做50多万例手术,在世界范围内每年估计超过100万例(4)。最近,从介入性心脏病学角度来看,这一数字几乎下降了一半,但主要是由于烟草和酒精使用的减少,更好的低脂肪饮食,他汀类药物和增加定期锻炼(在当地大气污染较少的情况下)。是否有可能为了治疗肥胖和2型糖尿病,我们必须走同样的道路?也就是说,大规模手术治疗,再次领先于生活方式的改变和药物治疗。我们应该建立肥胖/糖尿病研究所,拥有多学科团队的完整医院,配备内科医生、内分泌学家、减肥和代谢外科医生、心理学家和营养学家,以及公共卫生利益相关者。我们可以为世界上数百万受影响的患者进行手术,并真正对这两种慢性疾病产生影响,因为估计有3.5亿人受到影响(5)。我们应该足够快地开展手术,这样新的患者池就不会与我们每年治疗的患者重叠。随着袖式胃切除术(美国的第一选择)的迅速兴起,每年有20万患者接受手术,预计到2015年,全球每年的手术数量可能会低于50万例。这还不够;我们至少应该做这些数的10倍。即使每年有500万病人,我们也需要70年的时间来为所有人做手术。但这在短期内是一个合理的目标。这将需要一个相对简短、并发症少、死亡率极低、可重复且具有可接受的长期结果的程序。此时,腹腔镜套筒胃切除术比Roux-en-Y胃旁路术更适合这种情况(GERD可以通过药物治疗),因为它可能存在长期肠梗阻风险、溃疡风险、微量营养素严重缺乏、骨病和10%的低血糖/排便综合征(6,7)。套筒胃切除术可以更容易地进行修改,有多种选择。另外,我可以在同一时间间隔内做3个袖子,同时做一个胃旁路手术,因为我们有手术人手问题,前者更可取。肥胖和2型糖尿病是时候进行大规模手术治疗了吗?是的,现在正是时候。
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