[The metabolism of drugs and endogenous substrates in the organs of rabbits following partial hepatectomy and liver ischemia].

Abstract

The intensity of metabolism of hexenal, amidopyrine, phenacetin, promedol, acetone, hydrocortisone, testosterone and prostaglandin E2 by the isolated microsomes of the liver, kidneys, small intestinal mucosa and lungs was studied polarographically by the rate of oxygen absorption in experiments on 20 male rabbits four days following partial hepatectomy and liver ischemia. It was found that with both models of the liver damage there was observed a decrease of metabolism of amidopyrine, hexenal, phenacetin and an increase of metabolism of hydrocortisone and prostaglandin E2. In the lungs one could observe an increase of metabolism of the studies drugs following hepatectomy and its inhibition in liver ischemia. In the kidneys and intestine in both types of the liver damage contradirected changes in drug metabolism being of the compensatory character were observed.