[The anxiogenic activity of phenylethylamine in the social isolation test on mice].

Farmakologiia i toksikologiia Pub Date : 1991-11-01
I P Lapin, M V Slepokurov
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引用次数: 0

Abstract

One-day isolation of male albino mice of SHR strain significantly increased the level of social behaviour measured by the number and total duration of active contacts (sniffings). A putative endogenous anxiogen beta-phenylethylamine (5-12.5 mg/kg) inhibited the communication like human anxiogens corazole (10 mg/kg) and caffeine (200 mg/kg). Diazepam (1 mg/kg) prevented the action of phenylethylamine, phenibut (10-50 mg/kg) exerted no effect on it. The social isolation test during studying anxiogens and anxiolytics can be performed on mice as previously on rats.

[苯乙胺在小鼠社会隔离试验中的焦虑活性]。
通过主动接触(嗅探)的次数和总持续时间衡量,将SHR品系雄性白化小鼠隔离一天后,其社会行为水平显著提高。内源性焦虑原-苯乙胺(5-12.5 mg/kg)与人类焦虑原科拉唑(10 mg/kg)和咖啡因(200 mg/kg)一样,抑制了神经通讯。安定(1 mg/kg)对苯乙胺起抑制作用,苯乙酯(10 ~ 50 mg/kg)对苯乙胺不起作用。在研究焦虑剂和抗焦虑剂时,社会隔离测试可以像以前在大鼠身上进行一样在小鼠身上进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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