Synchronization-Inspired Co-Clustering and Its Application to Gene Expression Data

Abstract

In this paper, we propose a new synchronization-inspired co-clustering algorithm by dynamic simulation, called CoSync, which aims to discover biologically relevant subgroups embedding in a given gene expression data matrix. The basic idea is to view a gene expression data matrix as a dynamical system, and the weighted two-sided interactions are imposed on each element of the matrix from both aspects of genes and conditions, resulting in the values of all element in a co-cluster synchronizing together. Experiments show that our algorithm allows uncovering high-quality co-clusterings embedded in gene expression data sets and has its superiority over many state-of-the-art algorithms.