[Changes in the kallikrein-kinin system of patients with erythematous and hemorrhagic forms of erysipelas].

Abstract

The state of the kallikrein-kinin system of the blood (KKS): kallikrein (KK), prekallikrein (PK), general arginine-esterase activity (GAEA), alpha 1 inhibitor of protease (IP) and alpha 2-macroglobulin (MG). The initial period of the disease was characterized by an increase of the level of KK, GAEA, IP and MG and a reduction of PK. It was established that the maximal activation of KKS develops in patients with the erythematous form of erysipelas during the first days of the disease, with the hemorrhagic form--on the 2 week. During convalescence KKS indices showed the reverse dynamics but did not reach normal levels in most patients. It is suggested that there is a relationship of the "rapid" form of KKS activation with formation of erythematous erysipelas, the "slow"--with hemorrhagic erysipelas. It is recommended to use the KKS indices, primarily KK activity for prediction of hemorrhagic erysipelas at the early prehemorrhagic stage.