[Status of the thrombocytic-vascular component of the hemostasis system in the population of the Far North].

Abstract

As many as 141 residents of an urbanized region of the Far North (92 patients with coronary heart disease [CHD] and 49 normal persons) and 75 persons (57 natives and 18 newcomers) living in one of rural settlements in the Far North were examined for the thrombocytic-vascular component of the hemostasis system measured by the levels of stable metabolites of prostacyclins and thromboxane A2. Some characteristics of the coagulation component of the hemostasis system were also analyzed. All the persons examined were males aged 40-59 years. The prostacyclin/thromboxane ratio in the normal northerners did not differ from that in residents of Siberia. The patients with CHD living in the Far North for a long time demonstrated a greater shift of homeostatic balance toward increase of blood proneness to intravascular platelet aggregation, which strongly increases a risk of thrombotic complications. The natives living in the rural region of the Far North manifested a high prostacyclin generative activity and hypocoagulation changes in the plasma component of the hemostatic system.