{"title":"[The characteristics of the embryotoxic action of kalipsol].","authors":"Iu I Bandazhevskiĭ, A I Shimanovich","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":"54 5","pages":"58-9"},"PeriodicalIF":0.0000,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmakologiia i toksikologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.