Potential Of Kenikir (Cosmos Caudatus Kunth) Leaves Essential Oil Against Candida Albicans Atcc 10231 In Vitro

Medica Hospitalia : Journal of Clinical Medicine Pub Date : 2022-11-30 DOI:10.36408/mhjcm.v9i3.803

Siti Zainatun Wasilah, Ratih Hardisari, B. Martono, Wahyu Adi Pratama

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Abstract

BACKGROUND : Kenikir is a medicinal plant whose leaves are often consumed as vegetables. Kenikir leaves contain active compounds such as flavonoids, polyphenols, saponins, tannins, alkaloids and essential oils. These compounds are thought to be able to inhibit the growth of Mycobacterium tuberculosa and Candida albicans ATCC 10231 strains OBJECTIVE : The purpose of this study was to describe the effect of kenikir leaf essential oil on the growth of the Candida albicans ATCC 10231 strains. with 4 concentrations and 6 repetitions in Candida albicans and the concentration of kenikir leaf essential oil concentration of 0.5%, 1%, 1.5%, 2%, METHOD : This type of research is a pure experimental research by providing treatment in the form of giving essential oil of kenikir leaves with various concentrations on the growth of the Candida albicans ATCC 10231 strains. The inhibition test of kenikir leaf essential oil on the growth of the Candida albicans ATCC 10231 strains was carried out using the Kirby Bauer disk diffusion method. The research design used is Post Test Only with Control Group Design.Data obtained in the form of inhibition zone diameter, were analyzed using Variant Analysis (Anova), P£ 0,05 and continued with Post Hoc test. RESULT : The results showed that 0.5% essential oil concentration had a inhibition zone of 9.67 mm (moderate criteria); essential oil concentration of 1% with a inhibition zone of 9.72 mm with criteria moderate and 1.5% concentration with inhibition zone 11.86% with strong criteria and concentration 2% with inhibition zone 12.67 mm with strong criteria all concentrations affect the growth of Candida albicans with the most optimal concentration of 2% for the Candida albicans ATCC 10231 strains. CONCLUSION : The higher the concentration of kenikir leaf extract, the inhibitory effect on the growth of Candida albicans ATCC 10231 strains was also higher. KEYWORDS : Cosmos caudatus Kunth, Candida albicans ATCC 10231 strains, diameter of the inhibition zone

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Kenikir (Cosmos Caudatus Kunth)叶精油体外抗白色念珠菌Atcc 10231的作用研究

背景:Kenikir是一种药用植物，其叶子常被当作蔬菜食用。Kenikir叶子含有活性化合物，如类黄酮、多酚、皂苷、单宁、生物碱和精油。这些化合物被认为能够抑制结核分枝杆菌和白色念珠菌ATCC 10231菌株的生长。目的:本研究的目的是描述肯尼克叶精油对白色念珠菌ATCC 10231菌株生长的影响。方法:采用不同浓度的肯尼革叶精油对白色念珠菌ATCC 10231菌株的生长进行处理，为纯实验研究。采用Kirby Bauer盘片扩散法对白念珠菌ATCC 10231菌株进行抑菌试验。本研究采用后测+对照组设计。以抑制带直径的形式获得的数据，使用变异分析(Anova)进行分析，P < 0.05，并继续进行事后检验。结果:0.5%精油浓度的抑菌带为9.67 mm(中等标准);精油浓度为1%，抑菌区为9.72 mm，抑菌区为中度，抑菌区为1.5%，抑菌区为11.86%，抑菌区为2%，抑菌区为12.67 mm，抑菌区为强，所有浓度均影响白色念珠菌的生长，其中对白色念珠菌ATCC 10231菌株的最佳抑菌浓度为2%。结论:kenikir叶提取物浓度越高，对白色念珠菌ATCC 10231株生长的抑制作用也越强。关键词:尾状念珠菌，白色念珠菌ATCC 10231株，抑菌区直径

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Medica Hospitalia : Journal of Clinical Medicine

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