Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats
Filipe Jonas Federico da Cruz, Daniel Ferreira Almeida de Souza, Samila Fernandes dos Santos Anjos, Ana Paula Fernandes Barbosa, J. Marques, Svetlana Maria Wanderley de Barros, A. Santana, M. S. Moreira, M. Jucá
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Abstract
Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts to regarding the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant anti-inflammatory effect on the colon mucosa.
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