[The role of lipid peroxidation and the activity of energy metabolism enzymes in the pathogenesis of acute closed craniocerebral trauma].

Abstract

The state of lipid peroxidation and activity of dehydrogenases, transaminases and creatinphosphokinase was studied in rats and 94 patients with mild and average--severe head injuries. A relationship has been found between activation of peroxidation and reduction of activity of enzymes participating in energy reactions that along with activation of transamination evidences reduction of the energy charge of the body. Activation of peroxidation plays a major role in the development of posttraumatic brain edema and especially after mild head injury.