Synthesis, characterisation of schiff bases generated from salicylaldehyde with certain amino acids using a new established technique

Abstract

Amino acids are compounds that consist of an amine group, a carboxylic acid group, and a variable side chain. These molecules are very significant in biochemistry. Amino acids with uncharged amino groups can also undergo Schiff base production at physiological PH levels, presenting an additional possible pathway for metal complexes. In this investigation, four novel Schiff-base amino acid compounds were identified: 5Chlorosalcialdehyde-glycine (H2L1), 5-Chlorosalycialdehyde-alanine (H2L2), 5-Nitrosalycialdehyde-glycine (H2L3), and 5Nitrosalycialdehyde-alanine (H2L4) (H2L4). Condensation reaction product of substituted salicylaldehyde. With a few amino acids, glycine and -alanine, using an alternate technique. The innovation is the addition of 10-2mole sodium hydroxide as a novel catalyst to the traditional process of synthesizing Schiff bases. Elements (C.H.N) and spectroscopic techniques (IR, 1H, and 13C NMR) were used to describe the four Schiff bases. These techniques were successfully used to characterize the prepared Schiff bases