[Role of hormonal factors in the regulation of bone tissue metabolism in children with cerebral palsy].

Abstract

In the article are presented the results of examination of 98 patients (aged 6-16 years) with infantile cerebral paralysis. There were used X-ray and radioimmune investigations of bone age, enchondral ossification, state of foot bone structure and blood concentration of "osteotropic" hormones. Bone age corresponded mainly to the passport one; ossification rate overtake and deceleration have been revealed in a third of the examined children and concentric atrophy in 30% patients. Structural disturbances of osseous tissue as the different forms of osteoporosis have been detected in 89.5% cases. There have been stated direct correlation between the frequency of disturbances and the form of infantile cerebral paralysis. There have been noted reliable increase of hydrocortisone level and significant decrease of somatotropic hormone concentration (by 70% and 3.5-3.7 times as compared with the control) and sexual differences in concentrations of osteotropic hormones. The results are discussed from the point of view of neurohumoral relation disturbances and the presence of vegetative dystonia syndrome with predominance of sympathetic-adrenal system activity.