The influence of metoclopramide on the composition of human breast milk.

Acta paediatrica Hungarica Pub Date : 1991-01-01
T Ertl, E Sulyok, E Ezer, I Sárkány, V Thurzó, I F Csaba
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Abstract

Unlabelled: The breast milk prolactin (PRL) has been claimed to play a role in the control of electrolyte composition of the milk. Since metoclopramide has been shown to increase milk production in humans, we have made an attempt to investigate the production, the PRL and sodium concentrations in milk with (group I) and without (group II) maternal metoclopramide treatment (5 days, 30 mg/day). Both groups consisted of 11 mothers and their full-term newborn infants. The daily milk production was significantly higher in the treated group (276.4 +/- 36.6 vs 150.9 +/- 25.3 ml/day, p less than 0.01). The PRL measured by RIA was similar in the milk samples of the metoclopramide treated and control groups (80.5 +/- 17.7 vs 90.7 +/- 27.3 ng/ml). The sodium concentration in the milk of mothers taking metoclopramide was 22.1 +/- 1.6 mmol/l and 24.3 +/- 3.2 mmol/l in the control group (p = 0.59). On the 5th postnatal day the plasma PRL of the newborns of mothers treated with metoclopramide does not differ from the values of the control babies (29.8 +/- 2.6 vs 30.7 +/- 2.4 ng/ml) indicating that the amount of metoclopramide transferred into the milk has no apparent influence on the hypothalamo-hypophyseal axis of the neonate.

In conclusion: the maternal metoclopramide treatment augments the milk production without having any effect on the PRL and sodium concentration of human "mature" milk.

甲氧氯普胺对母乳成分的影响。
未标示:母乳催乳素(PRL)被认为在控制牛奶的电解质成分中起作用。由于甲氧氯普胺已被证明可以增加人类的产奶量,我们试图调查(第一组)和(第二组)母体使用甲氧氯普胺(5天,30毫克/天)时产奶量、乳中PRL和钠浓度。两组都由11位母亲和她们的足月新生儿组成。处理组的日产奶量显著高于对照组(276.4 +/- 36.6 vs 150.9 +/- 25.3 ml/d, p < 0.01)。经RIA测定的甲氧氯普胺处理组与对照组的乳样PRL相似(80.5 +/- 17.7 vs 90.7 +/- 27.3 ng/ml)。服用甲氧氯普胺母亲的乳钠浓度为22.1 +/- 1.6 mmol/l,对照组为24.3 +/- 3.2 mmol/l (p = 0.59)。产后第5天,经甲氧氯普胺治疗的新生儿血浆PRL值与对照组(29.8 +/- 2.6 vs 30.7 +/- 2.4 ng/ml)无明显差异,表明乳中甲氧氯普胺的量对新生儿下丘脑-垂体轴无明显影响。综上所述:母体甲氧氯普胺处理增加了产奶量,但对人类“成熟”乳的PRL和钠浓度没有任何影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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