[The effect of microsomal enzyme inducers on the renal transport of iodamide].

Farmakologiia i toksikologiia Pub Date : 1991-07-01
G P Ul'ianov, V V Lampatov
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Abstract

On the 3rd day after the last administration of phenobarbital (50 mg/kg orally, 4 days), benzonal (35 mg/kg orally, 4 days), zixorine (200 mg/kg orally, 4 days) and 3-methylcholanthrene (20 mg/kg subcutaneously, 2 days) the rats exhibited a decrease of iodamide secretion in the kidneys. The administration of zixorine to the dog (200 mg orally, 6 days) led to a significant decrease of iodamide transport in the first two weeks after discontinuation of the drug administration.

微粒体酶诱导剂对碘胺肾转运的影响。
在末次给药苯巴比妥(50 mg/kg口服,4 d)、苯并性(35 mg/kg口服,4 d)、zixorine (200 mg/kg口服,4 d)和3-甲基胆蒽(20 mg/kg皮下注射,2 d)后第3天,大鼠肾脏碘化物分泌减少。给狗服用zixorine (200 mg口服,6天),在停药后的头两周内,碘胺转运显著减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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