New Estimation Method of Total Creatine Phosphokinase Release in Early Stage in Acute Myocardial Infarction

Abstract

In this paper, we introduce a new estimation method for total creatine phosphokinase release based on a physiological model of the serum creatine phosphokinase (CPK) activity change that can be used to estimate the total CPK release accurately, as early as possible, without frequent blood sampling. The physiological model and a new calculation method were applied to the serum CPK activity change of patients who suffered acute myocardial infarction (AMI). According to the results, the physiological model showed good agreement with the serum CPK activity change and the estimated value of the total CPK release also agreed well with that calculated using the conventional technique with clinically acceptable accuracy.