Multiple serotonin receptors on large arterioles in striated muscle.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158900
N L Alsip, P D Harris, G E Durrant
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引用次数: 7

Abstract

In rat striated muscle, serotonin (5-hydroxytryptamine; 5-HT) constricts large arterioles (first-order; A1) via 5-HT2 receptor activation but dilates smaller arterioles via a 5-HT1-like receptor. In this preparation, A1 arterioles possess little basal tone. The purpose of this study was to determine if 5-HT would elicit A1 dilation if arteriolar tone was first induced. In anesthetized rats, A1 diameters of the cremaster muscle were measured via in vivo videomicroscopy. Topical application of angiotensin II caused a 26 +/- 3% constriction of the vessels. 5-HT dilated the preconstricted A1s by 36 +/- 7% while constricting normal tone A1s by 33 +/- 5%. This dilation was enhanced by blocking 5-HT2 receptors with LY53857, but abolished with methysergide, a 5-HT1 and 5-HT2 receptor antagonist indicating that the dilation was mediated by a 5-HT1-like receptor. Thus, A1 arterioles possess both 5-HT2 and 5-HT1-like receptors. The net result of 5-HT application in striated muscle, dilation or constriction, will depend on the initial tone of the vessels.

横纹肌大小动脉中的多种血清素受体。
大鼠横纹肌中血清素(5-羟色胺;5-HT)收缩大微动脉(一级;A1)通过5-HT2受体激活,但通过5- ht1样受体扩张较小的小动脉。在这个准备过程中,A1小动脉具有很少的基底张力。本研究的目的是确定如果首先诱导小动脉张力,5-HT是否会引起A1扩张。在麻醉大鼠中,通过活体视频显微镜测量胸肌A1直径。局部应用血管紧张素II引起26 +/- 3%的血管收缩。5-HT使预缩的A1s扩张36 +/- 7%,使正常音A1s收缩33 +/- 5%。LY53857阻断5-HT2受体可增强这种扩张,但使用5-HT1和5-HT2受体拮抗剂甲基塞吉特可消除这种扩张,这表明扩张是由5-HT1样受体介导的。因此,A1小动脉同时具有5-HT2和5- ht1样受体。5-HT应用于横纹肌的最终结果是扩张还是收缩,将取决于血管的初始张力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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