Simulation of the electromagnetic field and temperature distribution in magnetic nanoparticles hyperthermia

Abstract

In this article hyperthermia therapy of tumors by electromagnetic field in radio-frequency range is described. Electromagnetic fields are used to generate temperature distribution inside the tumor and in surrounding tissues. First equations allowing calculation of the magnetic field within human body in terms of magnetic vector potential A and under sinusoidal steady state are derived. Next Pennes bioheat equation in a human tissue under uniform material properties with respect to temperature T is solved. Heat generation is caused by Brown and Neel relaxation processes. Also power loss formula in ferrofluid is presented. At the and some numerical example is solved and influence of various particle parameters on generation power and temperature is discussed.