Machine learning based evaluation of functional index for coronary lesion severity

Due Minh Tran, M. Nguyen, Sang-Wook Lee
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引用次数: 4

Abstract

One of the physiology based clinical indices for coronary lesion severity, fractional flow reserve (FFR)is currently the gold standard for identifying the ischemia-causing stenosis in coronary circulation and for deciding revascularization of the clogged artery. In this study, we newly propose a machine learning based FFR prediction approach from geometric features of stenotic lesion and circulation conditions. We generated total 1,116 anatomic vessel models with various geometric features of a stenosis. FFR data were computed by 3D-0D coupled blood flow dynamics simulations. We employed a fully connected deep neural network model with four hidden layers and a sigmoidal activation function. The input layer has six neurons corresponds to geometric features of stenotic lesion as well as aortic pressure. This novel data-driven approach for near-real time assessment of coronary lesion severity has promising potential in on-site routine clinical practices.
基于机器学习的冠状动脉病变严重程度功能指标评价
血流储备分数(fractional flow reserve, FFR)是衡量冠状动脉病变严重程度的生理学临床指标之一,是目前鉴别冠状动脉血流缺血性狭窄和判断阻塞动脉血运重建的金标准。在这项研究中,我们提出了一种基于机器学习的基于狭窄病变几何特征和循环状况的FFR预测方法。我们生成了1116个具有不同狭窄几何特征的解剖血管模型。通过3D-0D耦合血流动力学模拟计算FFR数据。我们采用了一个全连接的深度神经网络模型,该模型具有四个隐藏层和一个s型激活函数。输入层有6个神经元,对应狭窄病变的几何特征和主动脉压力。这种新颖的数据驱动的近实时评估冠状动脉病变严重程度的方法在现场常规临床实践中具有很大的潜力。
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