{"title":"Machine learning based evaluation of functional index for coronary lesion severity","authors":"Due Minh Tran, M. Nguyen, Sang-Wook Lee","doi":"10.1145/3184066.3184079","DOIUrl":null,"url":null,"abstract":"One of the physiology based clinical indices for coronary lesion severity, fractional flow reserve (FFR)is currently the gold standard for identifying the ischemia-causing stenosis in coronary circulation and for deciding revascularization of the clogged artery. In this study, we newly propose a machine learning based FFR prediction approach from geometric features of stenotic lesion and circulation conditions. We generated total 1,116 anatomic vessel models with various geometric features of a stenosis. FFR data were computed by 3D-0D coupled blood flow dynamics simulations. We employed a fully connected deep neural network model with four hidden layers and a sigmoidal activation function. The input layer has six neurons corresponds to geometric features of stenotic lesion as well as aortic pressure.\n This novel data-driven approach for near-real time assessment of coronary lesion severity has promising potential in on-site routine clinical practices.","PeriodicalId":109559,"journal":{"name":"International Conference on Machine Learning and Soft Computing","volume":"40 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Conference on Machine Learning and Soft Computing","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/3184066.3184079","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
One of the physiology based clinical indices for coronary lesion severity, fractional flow reserve (FFR)is currently the gold standard for identifying the ischemia-causing stenosis in coronary circulation and for deciding revascularization of the clogged artery. In this study, we newly propose a machine learning based FFR prediction approach from geometric features of stenotic lesion and circulation conditions. We generated total 1,116 anatomic vessel models with various geometric features of a stenosis. FFR data were computed by 3D-0D coupled blood flow dynamics simulations. We employed a fully connected deep neural network model with four hidden layers and a sigmoidal activation function. The input layer has six neurons corresponds to geometric features of stenotic lesion as well as aortic pressure.
This novel data-driven approach for near-real time assessment of coronary lesion severity has promising potential in on-site routine clinical practices.