Two-Level Factorial Designs

Abstract

The term design of experiments in analytical chemistry is associated to the establishment of adequate experimental conditions when working in the laboratory or process conditions used in industry to improve the instrumental conditions and/or extract the highest information from the experimental data. This chapter presents practical problem-solving strategies used to obtain a product or chemical process with desirable characteristics in an efficient mode, focused on the use of full and fractional (2-level) designs. The information is presented as a tutorial and the main advantages and disadvantages are presented and discussed, emphasizing the effect of reduction of experimentation in the data quality.