Ebstein’s Anomaly, Possible Newly Implicated Drug Aetiology? A Case Report

Abstract

Ebstein’s anomaly is a congenital malformation of the heart that is characterized by downward displacement of an abnormal tricuspid valve into the right ventricle. It is rare, with an incidence of 1 in 200,000 live births. Etiology is unknown. Our patient was exposed to artemether-lumefantrine, ciprofloxacin, and ibuprofen (not previously linked with Ebstein’s anomaly) at about four weeks of gestation. An obstetric scan at 33 weeks’ gestation, was the first clue to the diagnosis.