Intrinsic Complexity of RR and QT Intervals at the Cellular Level

Abstract

We characterize the complexity of interbeat intervals (IBIs) and field potential durations (FPDs) of human-induced plurioptent stem cell-derived cardiomyocytes (hiPSC-CMs). The complexity is assessed using the multiscale entropy (MSE) method up to the scale of ten beats. The MSE profiles of healthy and diseased (long-QT syndrome) hiPSC-CMs show important differences, which demonstrate the usefulness of the method in the characterization of the cells and in the analysis of hereditary cardiac diseases. We show that the intrinsic complexity is possibly altered by the differentiation methods, as well as the age and mutations of the cells.