One double-stranded DNA probes as classifier of multi targeting strand

Abstract

In this paper, we investigate an alternative double-stranded probe (dsProbe) system as detection platform that employs a similarity-based classifiers in DNA strand displacement reactions. We formulate label propagation based on DNA toehold domain as classifier, where a node propagates to neighboring nodes according to their proximity. We observe mismatch attributes of DNA strand sequences to recognize the effect of this model. The attributes are position, length and location number of mismatches. We carry out simulation using Nupack software and also experimental investigation..