Clopidogrel-tetralodo mercurate ion association immobilized PVC membrane sensor for the determination of clopidogrel in pharmaceutical formulations

Abstract

Fabrication of the PVC membrane sensor incorporating clopidogrel-tetraido mercurate as an electro active material for the determination of clopidogrel bisulphate is demonstrated. Sensor matrix having a composition of PVC 32%, ion association 2.5% and Di-n-butyl phthalate 56.5 % showed best nernstian behavior in the concentration range 1×10⁻² −1×10⁻⁷ M with a lower detection limit of 2.9 × 10⁻⁸ M. Working pH range and response time was found to be 1.8–4.0 and 5s respectively. The sensor was fruitfully utilized for the quantification of clopidogrel from Clopilet tablets. Comparative studies on the various parameters that depend on the performance characteristics of the present sensor with that of the literature reports were also included.