Applications of gamma-interferon in cancer therapy.

Abstract

This review focuses on the use of gamma-interferon (gamma-IFN) in cancer therapy. Although clinical trials using gamma-IFN have yet to identify a treatment niche for this cytokine, these studies have led to a greater understanding of the pleiotropic effects of this molecule on the human immune response, as well as identification of the dose range required for optimal biologic response modification. Thus, continued efforts to clinically develop gamma-IFN are warranted.