K. Shaker, G. M. Saladino, C. Vogt, Yurika Katsu-Jiménez, B. Brodin, R. Kuiper, K. Andersson, Yuyang Li, Jakob C. Larsson, M. Svenda, Aida Rodriguez-Garcia, M. Toprak, Marie Arsenian-Henriksson, H. Hertz
{"title":"Laboratory x-ray fluorescence computed tomography for in vivo preclinical imaging","authors":"K. Shaker, G. M. Saladino, C. Vogt, Yurika Katsu-Jiménez, B. Brodin, R. Kuiper, K. Andersson, Yuyang Li, Jakob C. Larsson, M. Svenda, Aida Rodriguez-Garcia, M. Toprak, Marie Arsenian-Henriksson, H. Hertz","doi":"10.1117/12.2595614","DOIUrl":null,"url":null,"abstract":"Laboratory x-ray fluorescence (XRF) computed tomography (XFCT) with nanoparticles (NPs) as contrast agents now allows for in vivo preclinical imaging and longitudinal studies at low radiation dose. We present on developments of our XFCT arrangement capable of low-dose (<25 mGy) imaging with high signal-to-background resulting in high-spatial-resolution (200-400 μm) in vivo imaging of Ru, Rh and Mo NPs injected and accumulated locally in mice. We further demonstrate multiplexing capabilities by cross-talk-free separation of Ru, Rh and Mo XRF signal as well as envisioning the future of preclinical XFCT for active targeting and imaging of molecular markers (e.g., cancer cells).","PeriodicalId":160373,"journal":{"name":"Developments in X-Ray Tomography XIII","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developments in X-Ray Tomography XIII","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2595614","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Laboratory x-ray fluorescence (XRF) computed tomography (XFCT) with nanoparticles (NPs) as contrast agents now allows for in vivo preclinical imaging and longitudinal studies at low radiation dose. We present on developments of our XFCT arrangement capable of low-dose (<25 mGy) imaging with high signal-to-background resulting in high-spatial-resolution (200-400 μm) in vivo imaging of Ru, Rh and Mo NPs injected and accumulated locally in mice. We further demonstrate multiplexing capabilities by cross-talk-free separation of Ru, Rh and Mo XRF signal as well as envisioning the future of preclinical XFCT for active targeting and imaging of molecular markers (e.g., cancer cells).
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
