Comparative Immunogenic Response of Live Vaccine of Lasota and Mukteswar Strains of Newcastle Disease Virus by Different Routes of Inoculation in Layer Chicken

University of Sindh Journal of Animal Sciences (USJAS) Pub Date : 2022-12-31 DOI:10.57038/usjas.v6i04.5841

ABDUL WHAB MANZOOR, Sajjad Hussain, HAFIZ MUHAMMAD WAQAR, SADIA SARFARAZ, SHERAZ SHAHID, Samiullah, AFEEFA SHAFIQ, Sajjad Ali, RAIS AHMED, HALEEMA SADIA, MAHEEN MURTAZA, TASLEEM KAUSAR

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Abstract

Newcastle disease (ND) has been one of the great challenges to Poultry in Pakistan and dealt with vaccination. Mortality and morbidity that are associated with it are economically significant. Two vaccines produced against Newcastle disease virus are Live ND-LaSota and ND Mukteswar vaccines and their immunogenic effects in backyard poultry. For that purpose, a total 130 of 6-8 weeks old layer cockerels were inoculated with both vaccines by different routes including Ocular, drinking water and Injection and serum samples were collected at 14, 21 and 35 days’ post inoculation were analyzed by Heamaglutination inhibition test for antibody titers. The best route of administration for ND-LaSota was observed by ocular drops and ND- Mukteswar through injection. So it was concluded that both the vaccines needed booster doses in 4th to 5th week of primary inoculation. ND-LaSota vaccine was found to be best for primary induction.

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不同接种途径下新城疫病毒Lasota和Mukteswar活疫苗在蛋鸡体内的免疫原性比较

新城疫病(ND)是巴基斯坦家禽面临的重大挑战之一，目前已采取疫苗接种措施。与之相关的死亡率和发病率在经济上意义重大。两种针对新城疫病病毒的疫苗分别是ND- lasota活疫苗和ND Mukteswar活疫苗及其在家禽中的免疫原性效应。本实验以130只6-8周龄蛋鸡为试验材料，通过眼、饮水、注射等不同途径接种两种疫苗，分别于接种后14、21、35 d采集血清样品，采用血凝抑制试验检测抗体滴度。滴眼给药和注射给药是ND- lasota的最佳给药途径。因此，这两种疫苗都需要在初次接种后第4 ~ 5周进行加强接种。发现ND-LaSota疫苗对初次诱导效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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University of Sindh Journal of Animal Sciences (USJAS)

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