Penile multifocal mucocutaneous verruciform xanthoma clinically mimicking squamous cell carcinoma: A case report and a brief literature review

Abstract

Verruciform xanthoma is a rare benign condition of unknown aetiology that occurs mainly in the oral mucosa but occasionally involves the anogenital region and skin. These lesions, particularly when multiple, may clinically mimic malignant tumours and pose a diagnostic challenge. The characteristic histological feature is the presence of histiocytic infiltrates in the papillary dermis. We report a case of multifocal mucocutaneous verruciform xanthoma of the penis in a 75-year-old man, which clinically mimicked a squamous cell carcinoma. We highlight the importance of being aware of this benign condition and discuss the morphology, aetiopathogenesis and treatment options.